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Carcinoma of cervix

MedGen UID:
86222
•Concept ID:
C0302592
•
Neoplastic Process
Synonym: Cervical carcinoma
SNOMED CT: Carcinoma of cervix (285432005)
 
Monarch Initiative: MONDO:0005131

Definition

A carcinoma arising from either the exocervical squamous epithelium or the endocervical glandular epithelium. The major histologic types of cervical carcinoma are squamous cell carcinoma and adenocarcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCarcinoma of cervix

Professional guidelines

PubMed

Genitourinary Fistula: epidemiology, changing trends in etiology and management: A tertiary care institute's perspective.
Vikram S, Om Kumar Y, Arjun Singh S, Mahendra S, Deepak Prakash B, Shashank T, Priyank B, Rahul J, Shivcharan N, Gautam Ram C
Urologia 2024 May;91(2):243-248. Epub 2024 Mar 18 doi: 10.1177/03915603241238597. PMID: 38497528
Paclitaxel dimers assembling nanomedicines for treatment of cervix carcinoma.
Pei Q, Hu X, Liu S, Li Y, Xie Z, Jing X
J Control Release 2017 May 28;254:23-33. Epub 2017 Mar 27 doi: 10.1016/j.jconrel.2017.03.391. PMID: 28359677
Literature review with PGI guidelines for delineation of clinical target volume for intact carcinoma cervix.
Bansal A, Patel FD, Rai B, Gulia A, Dhanireddy B, Sharma SC
J Cancer Res Ther 2013 Oct-Dec;9(4):574-82. doi: 10.4103/0973-1482.126450. PMID: 24518699

Recent clinical studies

Etiology

Prognostic significance of poorly differentiated histology and impact of adjuvant chemotherapy in early squamous cell carcinoma of cervix uteri.
Luo H, Yao H, Xu X, Li Z, Zhao H, Zhu H
Cancer Med 2021 Apr;10(8):2611-2617. Epub 2021 Mar 18 doi: 10.1002/cam4.3780. PMID: 33733588Free PMC Article
Influence of Demographic and Reproductive Factors on Cervical Pre-Cancer and Cancer in Bangladesh.
Nessa A, Ara R, Fatema P, Nasrin B, Chowdhury A, Khan KH, Barua AR, Rashid MHU
Asian Pac J Cancer Prev 2020 Jul 1;21(7):1883-1889. doi: 10.31557/APJCP.2020.21.7.1883. PMID: 32711411Free PMC Article
Uterine artery embolisation.
Bhardwaj R
Indian Heart J 2012 May-Jun;64(3):305-8. doi: 10.1016/S0019-4832(12)60093-5. PMID: 22664816Free PMC Article
Clinicopathological features and prognosis of small cell carcinoma of the cervix.
Liu J, Li Y, Li S, Wang D, Hu T, Meng Y, Ma D, Cai H, Wang Z, Xiong C, Zhang H
J Huazhong Univ Sci Technolog Med Sci 2010 Oct;30(5):626-30. Epub 2010 Nov 10 doi: 10.1007/s11596-010-0554-x. PMID: 21063846
A study of carcinoma of uterine cervix with special reference to its causation and prevention.
Malhotra SL
Br J Cancer 1971 Mar;25(1):62-71. doi: 10.1038/bjc.1971.9. PMID: 5581303Free PMC Article

Diagnosis

Influence of Demographic and Reproductive Factors on Cervical Pre-Cancer and Cancer in Bangladesh.
Nessa A, Ara R, Fatema P, Nasrin B, Chowdhury A, Khan KH, Barua AR, Rashid MHU
Asian Pac J Cancer Prev 2020 Jul 1;21(7):1883-1889. doi: 10.31557/APJCP.2020.21.7.1883. PMID: 32711411Free PMC Article
Nodal metastasis of cervix carcinoma- As a probable cause of bone erosion.
Sethi S, Ramalingam V, Yadav M, Thulkar S
J Cancer Res Ther 2019 Oct-Dec;15(6):1260-1264. doi: 10.4103/jcrt.JCRT_374_18. PMID: 31898657
Role of DDX53 in taxol-resistance of cervix cancer cells in vitro.
Park SY, Kim WJ, Byun JH, Lee JJ, Jeoung D, Park ST, Kim Y
Biochem Biophys Res Commun 2018 Nov 30;506(3):641-647. Epub 2018 Oct 26 doi: 10.1016/j.bbrc.2018.10.145. PMID: 30454700
Adenoid cystic carcinoma of cervix: two cases report and review of the literature.
Benhayoune K, El Fatemi H, Bannani A, Melhouf A, Harmouch T
Pan Afr Med J 2015;20:77. Epub 2015 Jan 29 doi: 10.11604/pamj.2015.20.77.5720. PMID: 26090035Free PMC Article
Uterine artery embolisation.
Bhardwaj R
Indian Heart J 2012 May-Jun;64(3):305-8. doi: 10.1016/S0019-4832(12)60093-5. PMID: 22664816Free PMC Article

Therapy

Causal role of immune cells on cervical cancer onset revealed by two-sample Mendelian randomization study.
Zhao Z, Yan P, Zhang X, Yu X, Lv F, Gong M, Yang XA
Sci Rep 2024 Jun 28;14(1):14890. doi: 10.1038/s41598-024-65957-7. PMID: 38937531Free PMC Article
Concurrent Cisplatin-Based Chemoradiation in Squamous Cell Carcinoma of Cervix.
Hashmi H, Maqbool A, Ahmed S, Ahmed A, Sheikh K, Ahmed A
J Coll Physicians Surg Pak 2016 Apr;26(4):302-5. PMID: 27097702
Long-term outcome and prognostic factors for adenocarcinoma/adenosquamous carcinoma of cervix after definitive radiotherapy.
Huang YT, Wang CC, Tsai CS, Lai CH, Chang TC, Chou HH, Hsueh S, Chen CK, Lee SP, Hong JH
Int J Radiat Oncol Biol Phys 2011 Jun 1;80(2):429-36. Epub 2010 Jun 9 doi: 10.1016/j.ijrobp.2010.02.009. PMID: 20542643
Is interferon-alpha and retinoic acid combination along with radiation superior to chemo-radiation in the treatment of advanced carcinoma of cervix?
Basu P, Biswas J, Mandal R, Choudhury P
Indian J Cancer 2006 Apr-Jun;43(2):54-9. doi: 10.4103/0019-509x.25885. PMID: 16790941
Prevention of carcinoma of cervix with human papillomavirus vaccine.
Gavarasana S, Kalasapudi RS, Rao TD, Thirumala S
Indian J Cancer 2000 Jun-Sep;37(2-3):57-66. PMID: 11876611

Prognosis

Prognostic significance of poorly differentiated histology and impact of adjuvant chemotherapy in early squamous cell carcinoma of cervix uteri.
Luo H, Yao H, Xu X, Li Z, Zhao H, Zhu H
Cancer Med 2021 Apr;10(8):2611-2617. Epub 2021 Mar 18 doi: 10.1002/cam4.3780. PMID: 33733588Free PMC Article
Influence of Demographic and Reproductive Factors on Cervical Pre-Cancer and Cancer in Bangladesh.
Nessa A, Ara R, Fatema P, Nasrin B, Chowdhury A, Khan KH, Barua AR, Rashid MHU
Asian Pac J Cancer Prev 2020 Jul 1;21(7):1883-1889. doi: 10.31557/APJCP.2020.21.7.1883. PMID: 32711411Free PMC Article
Long-term outcome and prognostic factors for adenocarcinoma/adenosquamous carcinoma of cervix after definitive radiotherapy.
Huang YT, Wang CC, Tsai CS, Lai CH, Chang TC, Chou HH, Hsueh S, Chen CK, Lee SP, Hong JH
Int J Radiat Oncol Biol Phys 2011 Jun 1;80(2):429-36. Epub 2010 Jun 9 doi: 10.1016/j.ijrobp.2010.02.009. PMID: 20542643
Clinicopathological features and prognosis of small cell carcinoma of the cervix.
Liu J, Li Y, Li S, Wang D, Hu T, Meng Y, Ma D, Cai H, Wang Z, Xiong C, Zhang H
J Huazhong Univ Sci Technolog Med Sci 2010 Oct;30(5):626-30. Epub 2010 Nov 10 doi: 10.1007/s11596-010-0554-x. PMID: 21063846
Current overview of the role of Akt in cancer studies via applied immunohistochemistry.
Shtilbans V, Wu M, Burstein DE
Ann Diagn Pathol 2008 Apr;12(2):153-60. doi: 10.1016/j.anndiagpath.2007.12.001. PMID: 18325479

Clinical prediction guides

DNA methylation of miR-138 regulates cell proliferation and EMT in cervical cancer by targeting EZH2.
Chen R, Gan Q, Zhao S, Zhang D, Wang S, Yao L, Yuan M, Cheng J
BMC Cancer 2022 May 3;22(1):488. doi: 10.1186/s12885-022-09477-5. PMID: 35505294Free PMC Article
Nodal metastasis of cervix carcinoma- As a probable cause of bone erosion.
Sethi S, Ramalingam V, Yadav M, Thulkar S
J Cancer Res Ther 2019 Oct-Dec;15(6):1260-1264. doi: 10.4103/jcrt.JCRT_374_18. PMID: 31898657
Role of DDX53 in taxol-resistance of cervix cancer cells in vitro.
Park SY, Kim WJ, Byun JH, Lee JJ, Jeoung D, Park ST, Kim Y
Biochem Biophys Res Commun 2018 Nov 30;506(3):641-647. Epub 2018 Oct 26 doi: 10.1016/j.bbrc.2018.10.145. PMID: 30454700
Characterization of Toll-like receptor transcriptome in squamous cell carcinoma of cervix: A case-control study.
Aggarwal R, Misra S, Guleria C, Suri V, Mangat N, Sharma M, Nijhawan R, Minz R
Gynecol Oncol 2015 Aug;138(2):358-62. Epub 2015 May 27 doi: 10.1016/j.ygyno.2015.05.029. PMID: 26024767
Is interferon-alpha and retinoic acid combination along with radiation superior to chemo-radiation in the treatment of advanced carcinoma of cervix?
Basu P, Biswas J, Mandal R, Choudhury P
Indian J Cancer 2006 Apr-Jun;43(2):54-9. doi: 10.4103/0019-509x.25885. PMID: 16790941

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